2024年4月7-10日，云顶国际在美国圣地亚哥参加2024年美国癌症研究协会（AACR）年会，期间展示了20张海报，包括9项全人单抗、双抗、双抗ADC、类TCR抗体药物分子最新数据和11项临床前动物模型及药理药效研究的最新成果。

Modality	Abstract Number	Poster Title
mAb	LB130	Identification of fully human CCR8 antibodies that demonstrate excellent ADCC function, potent blocking activity, and robust anti-tumor immune responses
TCRm	6717	Targeting mutant KRAS proteins with novel TCR-mimic fully human antibodies
bsAb	2724	BCG020, a novel bispecific antibody targeting EGFR and CD70, is effective against EGFR and CD70 high expressed tumors
bsADC	2620	BCG016, a first-in-class bispecific antibody-drug conjugate targeting 5T4 and MUC1, demonstrates potent preclinical anti-tumor activity
	2618	BCG017, a bispecific ADC targeting PTK7 and EGFR exhibits anti-tumor efficacy in PDX models
	2619	A novel EGFR×HER3-targeting bispecific antibody drug-conjugate, BCG019, demonstrates robust anti-tumor efficacy in preclinical evaluation
	2617	BCG022, a novel HER3×MET bispecific antibody-drug conjugate (bsADC), demonstrates promising anti-tumor efficacy
	LB127	A first-in-class bispecific ADC targeting FOLR1 and MUC1 exhibits promising anti-tumor activity in a FOLR1low xenograft model
	2616	BCG033, a novel bispecific antibody-drug conjugate targeting PTK7 and TROP2, demonstrates preclinical efficacy against triple-negative breast cancer and other solid tumor xenografts

Abstract Number	Model(s)	Poster Title
113	B-hIL31/hIL31RA/hOSM/hOSMR mice	Generation and validation of a novel humanized IL-31/IL-31RA/OSM/OSMR mouse model
116	B-hPD-1/hPD-L1/hCD94/hNKG2A mice	Generation of humanized PD-1/PD-L1/CD94/NKG2A mice for evaluating novel combination therapies
123	B-hCD3EDG/h4-1BB mice	Establishment of humanized CD3EDG/4-1BB mice for testing novel T cell engagers
124	B-hTL1A mice	Validation of humanized TL1A mice for advancing preclinical research
125	B-hVEGFA mice	Development of humanized VEGFA models to assess preclinical efficacy of novel therapeutics in vivo
5339	B-hIL5/hIL5RA mice	Establishment of a humanized IL5/IL5RA mouse model to evaluate modulators of eosinophilic inflammation in vivo
5345	B-HLA-A11.1 mice B-HLA-A24.2 mice	Development and validation of humanized HLA mouse model platforms for preclinical evaluation of novel peptide vaccines
5346	B-hCD16A (CB-17 SCID) mice	A novel humanized CD16A model to evaluate efficacy of human antibody therapeutics in triggering ADCC
LB363	B-hNKP46 mice	A novel humanized NKP46 mouse model to support xenograft studies evaluating NK cell-based cancer immunotherapies
LB365	B-SDG rats	Generation of a novel severely immunodeficient Sprague Dawley rat model for xenograft studies
1531	B-hPD-1/hPD-L1 mice Aged mice	TIL analysis demonstrates different mechanisms underlying PD-1 resistance in animal models